Postdoctoral Researcher Position - Targeting Autoreactive Plasma Cells (TAP)

About BioMed X

BioMed X is an independent research institute with sites in Heidelberg, Germany, New Haven, Connecticut, XSeed Labs in Ridgefield, Connecticut, and a world-wide network of partner locations. We operate at the interface between academia and industry, performing biomedical research and drug discovery & development in the fields of oncology, immunology, neuroscience, platform technologies, and artificial intelligence. All our research projects are sponsored by leading pharmaceutical companies and conducted by early-career scientists recruited from the best schools around the world. The combination of global crowdsourcing with local incubation of the best research talents and ideas allows us to solve the biggest challenges in biomedical research. We stand for free, creative, and curiosity-driven research combined with a solid validation of results, timelines, and deliverables. We serve a large purpose in advancing translational biomedicine by leveraging synergies and fostering cross-pollination across disciplines.

About Team TAP

The objective of the group New Strategies to Target Autoreactive Plasma Cells (TAP), led by Dr. Eleonora Melzi, is to uncover the mechanisms underlying the development and persistence of autoreactive plasma cells and their pathogenic autoantibodies. By employing a combination of state-of-the-art single-cell transcriptomic and high-throughput antibody analysis, we aim to identify new biomarkers of B cell autoreactivity. Ultimately, our goal is to define novel therapeutic strategies specifically targeting autoreactive plasma cells, thus advancing the diagnosis, treatment, and prevention of autoimmune diseases.

The Position

We are seeking a passionate and innovative postdoctoral researcher to join our dynamic team. The ideal candidate will hold a PhD in the area of immunology, biochemistry, biotechnology, structural biology, or a related field, and possess a deep interest in antibody discovery and protein engineering. This role offers a unique opportunity to contribute to the development of innovative technologies aimed at characterizing plasma cells in the context of neurological autoimmune disorders.

Required skills

• Extensive experience in protein design and engineering.
• Proficiency in recombinant protein and antibody expression, purification, and characterization in mammalian cell systems.
• Experience with standard molecular biology techniques (e.g., cloning, vector design, plasmid construction, qPCR, Western blot, etc.)
• Demonstrated independent thinking and problem-solving skills.
• Excellent oral and written communication skills in English.
• Interest in mentoring junior researchers and working within interdisciplinary teams.

Additional preferred skills

• Previous experience in B cell and antibody research.
• Expertise in cell culture and immunological assays, including flow cytometry, ELISA, and ELISpot.
• Proficiency in affinity measurement techniques, such as SPR, BLI, and KinExa.
• Experience with computational protein design or modeling using Rosetta, AlphaFold, and/or deep learning approaches.

Our offer

• International, diverse, and positive work atmosphere, flexible working environment
• A competitive salary
• Access to training and lecture courses in-house as well as in neighboring research institutions on the Life Science Campus in Heidelberg
• Access to a vast network in science and industry.
• Job ticket, sponsored fitness contract, complimentary fresh fruit, soft drinks and chocolate, team recognition events, etc.
• The post is offered for a limited term until June 1, 2027, with the possibility of renewal
• The position is sponsored by Servier.

Candidates are requested to submit

• 1-page cover letter explaining the reasons of interest to join our team
• Curriculum Vitae outlining scientific interests, research achievements, and a record of publications
• 2 reference letters or contact information of 2 referees

If you are passionate about advancing the field of autoimmune disease research and eager to work in a dynamic and collaborative environment, we encourage you to apply.

The position is immediately available, and candidates will be evaluated on a rolling basis. Please submit your application to the attention of Dr. Eleonora Melzi before September 30, 2024, via our online Career Space. Interested individuals are also welcome to reach out with any questions.

At BioMed X we embrace diversity as we consider it the source of innovation. We are committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, ideology, sex, sexual orientation, age, gender identity or gender expression, national origin, or disability.