Postdoctoral Researcher Position - Biomarker Detection in the Brain

About BioMed X

BioMed X is an independent research institute with sites in Heidelberg, Germany, New Haven, Connecticut, XSeed Labs in Ridgefield, Connecticut, and a world-wide network of partner locations. We operate at the interface between academia and industry, performing biomedical research and drug discovery & development in the fields of oncology, immunology, neuroscience, platform technologies, and artificial intelligence. All our research projects are sponsored by leading pharmaceutical companies and conducted by early-career scientists recruited from the best schools around the world. The combination of global crowdsourcing with local incubation of the best research talents and ideas allows us to solve the biggest challenges in biomedical research. We stand for free, creative, and curiosity-driven research combined with a solid validation of results, timelines, and deliverables. We serve a large purpose in advancing translational biomedicine by leveraging synergies and fostering cross-pollination across disciplines.

About the Team

The objective of the group Biomarker Detection in the Brain (BDB), headed by Dr. Khulan Sergelen is to develop an in vivo continuous monitoring biosensor for direct detection of small molecule biomarkers in brain tissue of rodent models for elucidating pharmacodynamic (PD) effect and pharmacokinetic (PK) parameters of drugs against neuropsychiatric diseases. Our team will explore the multifaceted task of continuous monitoring biosensor development, including molecular design and assay development, biocompatible sensor architecture, and optical sensor integration for in vivo monitoring.

The Position

The ideal candidate would have a PhD in Biochemistry, Biotechnology, Material Science & Engineering, or a related field and a strong background in bioassay development. The candidate will develop bioassays to be integrated into an optical fiber-based biosensor device for in vivo measurements. The candidate should be enthusiastic about assay development and will work within a multidisciplinary team in the field of neuroscience, physics, physical chemistry, and nanotechnology.

Required Skills

• Experience in designing, characterising and validating assays for biosensor integration
• Strong analytical skills
• Understanding of PK/PD studies
• Understanding of biocompatibility concepts for in vivo deployment of biosensors
• Ability to work independently and in an interdisciplinary team
• Curiosity and willingness to learn new skills
• Excellent communication skills in English

Additional preferred skills

• Experience working with aptamers
• Neuroscience background
• FELASA certification for animal experiments
• Experience with surgical techniques in rats is a plus

Our offer

• International, diverse, and positive work atmosphere, flexible working environment
• Access to training and lecture courses in house as well as in neighboring research institutions on the Life Science Campus in Heidelberg
• Access to a vast network in science and industry.
• Job ticket, sponsored fitness contract, complimentary fresh fruit, soft drinks and chocolate team recognition events, etc.

The post is offered for a limited term until August 31st 2025 with the possibility of extension up to February 28th 2026. The position is sponsored by Boehringer Ingelheim.

Candidates are requested to submit

• 1-page cover letter explaining the reasons of interest to join our team
• Curriculum Vitae outlining scientific interests, research achievements, a record of publications, future personal goals and extra-scientific passions
• 2 reference letters

The position is available immediately. Please submit your application to the attention of Dr. Khulan Sergelen, via our online Career Space. Applications will be considered on a rolling basis.

At BioMed X we embrace diversity as we consider it the source of innovation. We are committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, ideology, sex, sexual orientation, age, gender identity or gender expression, national origin, disability, or veteran status.