Job Offer #2021-J12 closed since January 31, 2022
Postdoctoral Position (all genders) Discovery of Synthetic Lethal Interactions in DNA Repair (SDR)
About BioMed X
BioMed X is an independent research institute located on the campus of the University of Heidelberg in Germany. Together with our partners, we identify big biomedical research challenges and provide creative solutions by combining global crowdsourcing with local incubation of the world’s brightest early-career research talents. Each of the highly diverse research teams at BioMed X has access to state-of-the-art research infrastructure and is continuously guided by experienced mentors from academia and industry. At BioMed X, we combine the best of two worlds - academia and industry - and enable breakthrough innovation by making biomedical research more efficient, more agile, and more fun.
About Team SDR
Due to their roles in response to chemotherapy and radiotherapy, DNA repair and DNA replication proteins have become an important target in the field of oncology. With the goal of personalizing cancer therapy, knock-out screens provide valuable targets for initial stages in drug development.
Recent advances in the CRISPR/Cas9 technology enabled development of screening strategies. In team SDR, we employ custom designed and genome-wide libraries, pooled and arrayed screens to discover novel mechanisms of DNA Repair. The objective of the group, headed by Dr. Özdemirhan Serçin is to identify and characterize new drug targets in DNA Repair and DNA Replication aiming at increasing the efficiency of clinically used DNA damaging drugs. Building on the success of team DDC (DNA Damage in Cancer) here at BioMed X Institute, team SDR focuses on screens in cells deficient in DNA Repair proteins and aims to unravel new synthetic lethal interactions between DNA Repair genes.
We are looking for highly enthusiastic researchers to broaden our think-tank with their intellectual power and technical excellence. The ideal candidate should have a PhD degree in molecular biology, cell biology, biochemistry or in a related field, a strong background in DNA Repair or DNA Replication fields, documented by peer-reviewed scientific publications.
- Strong background in DNA repair / DNA replication
- Cell Culture: Culturing, transfection and infection of cell lines
- Biochemistry wet-lab skills: immunoblotting, PCR, cloning…
- Experience in CRISPR/Cas9-based techniques
- Fluorescent microscopy
- Cell sorting
- Independent Thinking
- Experienced to work in interdisciplinary teams
- Excellent communication skills in English
Additional preferred skills
- Experience in using ImageJ/ FiJi software and Linux
- Graphpad Prism or Basic R programming.
- High-throughput microscopy
- DNA fiber assay
- Any additional DNA Repair assays
What we offer
The post is offered for a limited term until 31 October 2023 with the option of an additional year of extension. * International, diverse, and positive work atmosphere, flexible working environment * A competitive salary * Access to training and lecture courses in house as well as in neighboring research institutions on the Life Science Campus in Heidelberg * Access to a vast network in science and industry. * Job ticket (region-wide public transportation), sponsored fitness contract, complimentary fresh fruit, chocolate, soft drinks, team recognition events, etc. The position is sponsored by Merck. .
Candidates are requested to submit
- 1-page cover letter explaining the reasons of interest to join our team
- Curriculum Vitae outlining scientific interests, research achievements, a record of publications, future personal goals and extra-scientific passions
- 2 reference letters
The position is available as of 01 February 2022. Please submit your application to the attention of Dr. Özdemirhan Serçin before 31 January 2022 via the online career space on this website.